Guadalupe and Josefina Hinojosa were born in Havana, Cuba on November 25, 1912, to Diego Francisco Hinojosa and Maria de Jesus Alcala. Joined at the sternum and abdomen (xipho-omphalopagus), the sisters appeared as a sideshow attraction until a surgeon in San Antonio decided that he could separate the little girls. They underwent the surgery in 1917, at the age of five. Josefina, the larger, stronger twin, was given the shared liver. Without a liver, Guadalupe quickly died.